The addition of fluoxetine to cognitive behavioural therapy for youth depression (YoDA-C): Study protocol for a randomised control trial

CG Davey; AM Chanen; SM Cotton; SE Hetrick; MJ Kerr; M Berk; OM Dean; K Yuen; M Phelan; A Ratheesh; MR Schäfer; GP Amminger; AG Parker; D Piskulic; S Harrigan; AJ Mackinnon; BJ Harrison; PD McGorry

Journal article

The addition of fluoxetine to cognitive behavioural therapy for youth depression (YoDA-C): Study protocol for a randomised control trial

CG Davey, AM Chanen, SM Cotton, SE Hetrick, MJ Kerr, M Berk, OM Dean, K Yuen, M Phelan, A Ratheesh, MR Schäfer, GP Amminger, AG Parker, D Piskulic, S Harrigan, AJ Mackinnon, BJ Harrison, PD McGorry

Trials | BMC | Published : 2014

DOI: 10.1186/1745-6215-15-425

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Abstract

Background: The aim of the Youth Depression Alleviation-Combined Treatment (YoDA-C) study is to determine whether antidepressant medication should be started as a first-line treatment for youth depression delivered concurrently with psychotherapy. Doubts about the use of medication have been raised by meta-analyses in which the efficacy and safety of antidepressants in young people have been questioned, and subsequent treatment guidelines for youth depression have provided only qualified support. Methods/Design: YoDA-C is a double-blind, randomised controlled trial funded by the Australian government's National Health and Medical Research Council. Participants between the ages of 15 and 25 y..

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University of Melbourne Researchers

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Grants

Awarded by Seventh Framework Programme

Funding Acknowledgements

The trial is supported by a National Health and Medical Research Council (NHMRC) Project Grant (APP1024570). The imaging component of the study is supported by an additional NHRMC Project Grant (APP1064643). CGD is supported by an NHMRC Clinical Career Development Fellowship (APP1061757). SMC is supported by an NHMRC Career Development Fellowship (APP1061998). SEH is supported by an NHMRC Early Career Fellowship (APP567062). MB is supported by an NHMRC Senior Principal Research Fellowship (APP1059660). OMD is supported by a 2012 NARSAD Young Investigator Grant. BJH is supported by a NHMRC Clinical Career Development Fellowship (APP628509).